April 29, 2010
I have been guesting at a conference on cell culture engineering. At this conference, researchers share knowledge and innovations for engineering the processes for making medicines known as biopharmaceuticals (large molecule cancer drugs, heart attack drugs, etc.). These drugs are manufactured on a large scale by harnessing the microscopic cellular machinery of a massive number of cells in culture.
I learned that cells in culture act just like humans, if you overfeed them they will be lazy and not make the desired product. As I walked through the poster session last evening, I was struck by the importance of nutrition and environment on the productivity of cells to make these biopharmaceuticals.
In fact, researchers demonstrated that changes to the diet of the cell culture media (the food stream) could increase the productivity of the cells by 2x and more! Apparently, in cell culture there is an equivalent of substituting a diet of ice cream with a well balanced diet of proteins and carbohydrates.
There were also several posters showing that manipulating key environmental conditions, such as temperature, could lead to increased productivity. For example, most cell culture processes are run at normal body temperature. One researcher showed that cooling the culture several degrees from normal body temperature increased the productivity of the cells. Make them shiver — their machinery runs faster! Like the cells, I know that I swim faster in cooler water I run faster when the weather is cooler (until it requires too much bundling up and I’ll then head to the indoor gym).
The cells (and their researchers) reminded me that in order to achieve excellent performance over the long term we should all eat a balanced diet and stay cool. Thus, today’s long view advice:
- Eat a balanced diet.
- Stay cool for improved performance.
Are you eating right and staying cool?
April 19, 2010
It has been an awkward few weeks with no Long View posts to share. It’s not that my life has been dull or without opportunity to learn new Long View axioms. To the contrary, I have learned much these past few weeks, I have even written posts to allow myself to process and integrate new ideas in my thinking, but I have chosen not to share because of the long view tenets:
- Act with Dignity – be worthy of honor or respect
- Be Tactful – be sensitive in dealing with others or with difficult issues
- Cultivate Decorum – behavior in keeping with good taste and propriety
My most recent (unshared) posts might be construed to lack one or more of those tenets. As such, I have chosen to learn from but not publish those posts.
I respect even my most challenging relationships for the long view. 🙂
Are you acting with dignity, tact, and decorum?